The goal of this study is to evaluate trends in blood biomarkers and their relation with aortic root diameter, aortic valve abnormalities and left ventricular function in patients with BAV disease. Furthermore, we aim to identify and validate new potentially important blood biomarkers, which can be implemented in the clinical management of these patients. Furthermore, certain imaging biomarkers may precede clinical deterioration. Therefore we aim to establish imaging parameters associated with aortic valve dysfunction or aortic dilatation
The knowledge gained in this study will help us to individualize current treatment protocols and to derive novel therapeutic strategies. Patients at low risk of complications could be seen less frequently, and those at high risk could be seen more frequently and treated more timely if necessary.