(HF-IMAGE) Development of in vivo models for research use, drug discovery and drug development

Project summary

The HF-IMAGE project aims to improve the management of heart failure (HF) through development of a standardized experimental model and a novel biomarker for the detection of fibrosis. Combined with quantitative imaging, this biomarker will be applicable to optimize the clinical and therapeutic management of several groups of heart failure patients.

After this project, these models combined with quantitative imaging and a diagnostic probe offer great opportunities for exploitation as a drug development platform for HF. Furthermore, a novel clinical non-invasive imaging method will be developed for detection of cardiac fibrosis as an early biomarker for HF, based on a proprietary radiolabeled peptide. This biomarker will be applicable to optimize the clinical and therapeutic management of several groups of HF patients.