(LONGITOOLS) Dynamic longitudinal exposome trajectories in cardiovascular and metabolic non-communicable diseases
Lifestyle and living environments have changed. Environmental exposures, including air and noise pollution, the built environment and an individual’s psychological, social and lifestyle determinants, interplay with genetic factors leading to increasing the risk of developing cardiovascular and metabolic non-communicable diseases, such as obesity, type 2 diabetes, heart diseases and atherosclerosis. The LongITools project will study and measure how longitudinal exposure to these environmental factors contribute to the risk of developing such diseases across the life-course. The project will take an exposome or holistic-based approach, linking individual and societal health to the environment to define the disease pathways and the points at which to best intervene during the life-course to reduce the risks. A key objective will be to generate new monitoring and prediction methods and tools which can also translate into innovative healthcare and policy options.
This ambitious project includes partners from 15 research institutions and three small and medium-sized enterprises across eight European countries with expertise in epidemiology, genetics, epigenetics, metabolomics, lifestyle, mathematics, economics, policy making and sensor technology.
LONGITOOLS’s overarching aim is to incorporate an exposome-based approach to the developmental and life-course origins of cardiometabolic non-communicable diseases. We will use and enrich a unique repertoire of high-dimensional complementary data across the life-course, including prospective birth cohorts and longitudinal studies in adults, register-based cohorts, randomised controlled trials and biobanks.
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