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Dissecting the mechanisms of malignant transformation in del(5q) myelodysplastic syndrome to selectively target the disease-initiating hematopoietic stem cells

Project summary

Myelodysplastic syndrome (MDS) patients have an increased risk of leukemia. This project investigates the mechanisms of malignant transformation of hematopoietic cells containing a del(5q) mutation.


This project will generate new knowledge that may lead to the development of novel drugs targeting MDS without affecting healthy hematopoietic cells, ultimately increasing the therapeutic window in leukemia.

More detailed information

Principal Investigator:

Role Erasmus MC:



Project website:

Funding Agency:

KWF Kankerbestrijding /
Young Investigator Grant