Understanding the role of the gut microbiome in the pathogenesis and prevention of dementia

Project summary

Every person carries approximately two kilos of bacteria in the intestine. These bacteria send signals to our brain via molecules in the blood. The human genetic material determines which groups of gut bacteria thrive. Lifestyle and use of medicine also determine the bacterial composition in the gut.
The aim of this project is to understand how the combination of intestinal bacteria, lifestyle, medication and our DNA influence the development of dementia.

This project will assess which bacteria actually protect the brain against development of dementia. This can lead to new medicines or interventions in the field of lifestyle, with which dementia can be prevented.